The best way to deal with these folks is to first identify who they are. Ask yourself these four questions. While you can do it mentally, it might be helpful to jot down the answers. They will help you discover those who might be your life and peace-of-mind in an adverse way.
1. What kinds of qualities in other people do you find emotionally draining or exhausting? What kinds of people do you find it difficult to be around?
2. Are there currently any such people in your life with whom you don't feel you have set appropriate boundaries?
3. What would setting firmer boundaries with these people look like? What would be the benefit of setting such boundaries?
4. What keeps you from doing this?
Your answers to these questions can help you discover those individuals who might be draining you physically and emotionally. Then choose one energy vampire in your life and commit to setting firmer boundaries with this person. "This means saying no when you would normally say yes." This could mean limiting the amount of time you spend with them or the amount of mental energy you give them. It might also mean telling them which subjects are distressing to you and telling them to please refrain from discussing them...at least in any great length. And as soon as you begin to feel depleted, give yourself permission to leave without feeling any guilt. "Sorry Aunt Eggberta and Uncle Gomer, I gotta run now."